In vivo magnetic targeting of vectors

Weber et al. bound lentiviral particles to the surface of the TurboBeads utilizing biotin-streptavidin interactions and magnetically directed them into cells (magnetofection). It was shown that TurboBeads can also be utilized in vivo for the targeting of nucleic acids via magnetically driven lentiviral transfection. Thereby, lentiviral particles were injected and magnetically directed to the tail region of mice. No toxic effects could be observed during seven days of in vivo testing.

​Weber et al. J. Biotechnol. 2009 (link)