Amine-Functionalization to measure localized oxygen levels via fluorescence

Turbobeads (with Amine groups) were functionalized by Van Druff et al. with oxygen-sensitive lumiphores via a stable amide bond. With this system oxygen partial pressures could be measured via fluorescence intensity and may be utilized as sensors for tumor metastasis. The low toxicity of the used Turbobeads allow in vivo applications of this sensing technology.

Van Druff et al. IFMB Proceedings 2010 (link)