Alhogail displayed that TurboBeads bound to gold surfaces by specific peptide sequences can be used to detect listeria within just one minute of measurement time, directly from milk and meat samples.
Abhogail et al. Biosens. Bioelectron. 2016 (link)
In their work published in Nanomedicine, Herrmann et al. show that carbon coated metallic nanoparticles (=TurboBeads) are non toxic to mice in short and long-term in vivo experiments.
Herrmann et al. Nanomedicine 2016 (link)
Schneider et al. display that biomolecules can be attached to the surface of TurboBeads by click chemistry, and in a second step can be released unharmed from the particle surface by the use of a mild release agent (buffered oxide etch). Both chemistries (click chemistry and Si-F) are fully orthogonal to standard biochemical reactions.
Schneider et al. Chem. Commun. 2016 (link)
Due to its optical clarity the eye represents an especially interesting subject for in vivo studies. Dengler et al. used amine-functionalized magnetic TurboBeads to target the eye of a mice in vivo. For this the nanoparticles were labeled with Tc to allow the monitoring of the radioactive biodistribution. Further in vitro cytotoxicity of the functionalized TurboBeads was investigated.
Dengler et al. AIP Conf. Proc. 2010 (link)
Impurities in the human blood system such as lead, drugs or immune response markers may lead to severe diseases and have to be rapidly removed from blood in emergency settings. Surface functionalized TurboBeads were by used by Herrmann et al. to remove such harmful substances from whole human blood. Ethylenediaminetetraacetic acid groups (EDTA), antidigoxin antibody fragments (FAB), or entire antibodies (anti-hIL-6) were attached to the nanoparticles. These functionalizations were shown to bind specifically to lead, digoxin and human interleucin 6. Due to the unique properties of the functionalized TurboBeads with high magnetic properties the impurities could be removed magnetically from whole human blood within only a few minutes.
Herrmann et al. Small 2010 (link)
Weber et al. bound lentiviral particles to the surface of the TurboBeads utilizing biotin-streptavidin interactions and magnetically directed them into cells (magnetofection). It was shown that TurboBeads can also be utilized in vivo for the targeting of nucleic acids via magnetically driven lentiviral transfection. Thereby, lentiviral particles were injected and magnetically directed to the tail region of mice. No toxic effects could be observed during seven days of in vivo testing.
Weber et al. J. Biotechnol. 2009 (link)
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