In their article on the initiation of breast cancer published in PNAS earlier this year, Gupta et al. utilized TurboBeads Carboxy nanoparticles for immunoprecipitation reactions, in the search for ligands for the compound C108.
link to original publication
Alhogail displayed that TurboBeads bound to gold surfaces by specific peptide sequences can be used to detect listeria within just one minute of measurement time, directly from milk and meat samples.
Abhogail et al. Biosens. Bioelectron. 2016 (link)
A patch antenna is made from a composite of polyaniline and carbon coated nanomagnets for operation at 4.5 GHz.
Hamouda et al. IEEE Explore, Antennas and Propagation 2016 (link)
In their work published in Nanomedicine, Herrmann et al. show that carbon coated metallic nanoparticles (=TurboBeads) are non toxic to mice in short and long-term in vivo experiments.
Herrmann et al. Nanomedicine 2016 (link)
By combining MnO2 nanoplatelets with carbon coated metallic nanoparticles (TurboBeads), Zhi et al. is able to generate new super-capacity materials with increased electric conductivity and improved overall performance, very close to the theoretical value for manganese oxide (1200 F / g).
Zhi et al. ACS Appl. Mater. Interfaces 2016 (link)
Najafpour et al. further modified silica coated TurboBeads with a manganese oxide coating. They showed that the resulting material was a well performing catalyst for water oxidation (in the presence of Ce(VI) and Ru complexes) that could be recovered from the reaction mixture rapidly by the use of magnetism.
Naijafpour et al. Int. J. Hydrogen Energ. 2016 (link)
Schneider et al. display that biomolecules can be attached to the surface of TurboBeads by click chemistry, and in a second step can be released unharmed from the particle surface by the use of a mild release agent (buffered oxide etch). Both chemistries (click chemistry and Si-F) are fully orthogonal to standard biochemical reactions.
Schneider et al. Chem. Commun. 2016 (link)
TurboBeads with complexion groups covalently attached to the carbon surface were utilised to enrich dissolved copper from environmental waters prior to analysis by chelation ion chromatography. Detection limits for copper in sea water were as low as 0.1 ng / ml (i.e. 0.1 ppb).
Wei et al. Talanta 2015 (link)
Due to its optical clarity the eye represents an especially interesting subject for in vivo studies. Dengler et al. used amine-functionalized magnetic TurboBeads to target the eye of a mice in vivo. For this the nanoparticles were labeled with Tc to allow the monitoring of the radioactive biodistribution. Further in vitro cytotoxicity of the functionalized TurboBeads was investigated.
Dengler et al. AIP Conf. Proc. 2010 (link)
Impurities in the human blood system such as lead, drugs or immune response markers may lead to severe diseases and have to be rapidly removed from blood in emergency settings. Surface functionalized TurboBeads were by used by Herrmann et al. to remove such harmful substances from whole human blood. Ethylenediaminetetraacetic acid groups (EDTA), antidigoxin antibody fragments (FAB), or entire antibodies (anti-hIL-6) were attached to the nanoparticles. These functionalizations were shown to bind specifically to lead, digoxin and human interleucin 6. Due to the unique properties of the functionalized TurboBeads with high magnetic properties the impurities could be removed magnetically from whole human blood within only a few minutes.
Herrmann et al. Small 2010 (link)
Based on their high magnetic properties, TurboBeads represent a promising substrate for semi-heterogeneous catalysts. In this paper, Wittmann et al. functionalized TurboBeads nanoparticles with a pyrene-tagged palladium NHC complex. This chemical group was shown to immobilize reversibly on the surface of the TurboBeads and the catch/release could be controlled by adjusting the reaction temperature. This catalyst catch-release concept was investigated in detail for the hydroxycarbonylation of aryl halides in water. 14 catalytical cycles utilizing the same material were shown and no effect on the velocity of the reactions could be observed.
Angew. Chem. Int. Ed. 2010 (link)
Schätz et al. functionalized TurboBeads with azabis-(oxazoline)-copper(II) complexes via an azide (“click”) reaction. The catalytic performance for the enantioselctive benzoylation of diols was addressed in batch and continuous flow reactors. In the continuous flow reactor a high degree of agitation was achieved, as a rotating magnetic field was applied in the reaction chamber. This led to a magnetically fixated, moving catalyst bed with highly increased mass transfer rates.
Schätz et al. Chem. Mater. 2010 (link)
Highly magnetic TurboBeads were shown to adsorb Au ions at high efficiencies. This effect is based on the strong affinity between the carbon surface of the nanoparticles and the precious metal ions and is assisted by the reductive properties of the particles. Rossier et al. added Turbobeads to an aqueous gold solution. The gold ions were reduced to Au(0) in the proximity of the particles, deposited on the particle surface and could be removed magnetically. The system showed a high yield down to initial Au concentrations in the ppb level. In a second step the gold could be released from the particles by washing them in aqua regia displaying the possibility of recycling the magnetic TurboBeads.
Rossier et al. J. Mater. Chem. 2009 (link)
Highly magnetic carbon coated Fe-based core TurboBeads were functionlized by Koehler et al. with ethylenediaminetatraacetic acid (EDTA) similar chelator groups (DTPA). These chelating agents are known for their excelent binding properties to heavy metals. Here, the performance of functionalized TurboBeads to extract Cu, Cd and Pb from aqueous solutions was investigated at various initial concentrations from 1 ppb to 100 ppm.
Koehler et al. Small 2009 (link).
Weber et al. bound lentiviral particles to the surface of the TurboBeads utilizing biotin-streptavidin interactions and magnetically directed them into cells (magnetofection). It was shown that TurboBeads can also be utilized in vivo for the targeting of nucleic acids via magnetically driven lentiviral transfection. Thereby, lentiviral particles were injected and magnetically directed to the tail region of mice. No toxic effects could be observed during seven days of in vivo testing.
Weber et al. J. Biotechnol. 2009 (link)
Today’s muscle replacement devices lack elastic properties and, therefore, the required flexibility. Fuhrer et al. illustrated the enormous potential of embedding TurboBeads in a flexible polymer hydrogel matrix (poly(2-hydro-xyethyl methacrylate)). The influence of different polymer linkers as well as the overall elongation performance in the presence of applied magnetic fields was investigated in detail.
Fuhrer et al. Small 2009 (link)
Metals and polymers do not mix well, which makes the formation of magnet/polymer nanocomposites impossible. Luechinger et al. showed in their work that the application of an ultrathin graphene like carbon layer to a metal core nanoparticle drastically increases its mixing capability with polymers. In detail, this work describes the dispersion of carbon coated TurboBeads into poly(methylmethacrylate) (PMMA) and poly(ethylene oxide) (PEO) polymers. The resulting magnetic system is of special interest for injection molding and the work shows that a magnetic motor core could be formed from the polymeric material.
Luechinger et al. Adv. Mater. 2008 (link)
First report of the chemical functionalization of a carbon coated metallic nanoparticle. Grass et al. Angew. Chem. Int. Ed. (2007) (link)
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